In order to investigate the influents of Panax ginseng(white gir, .ginseng) on the anesthetic effect and toxic effect of alcohol, experh
.had been carried out with albino rabbits, mongolian dogs and mice.. BTECH09esa4
The anesthetic effect of alcohol was observed by measuring the induction time, .anesthetic time, recovery time and duration from the beginning of induction to :the recovery of anesthesia (total tine), respectively, and toxic effect (LDso) of
.alcohol was measured. In addition to these experiments, alcohol concentration in .blood, blood sugar level, serum transaminase (GOT and GPT) activities and .serum alkaline phosphatase adivity were measured.
Also in order to study the clinical effects of alcohol in healthy students, code -substitution, response time and muscle coordination were tested. The results were -obtained as follows.
1. In the rabbits and mongolian dogs, the induction time of anesthesia by the .administration of alcohol was delayed by the pretreatment of ginseng but recovery .time and total time of anesthesia were markedly shortened.
2. The blood alcohol concentration was decreased by the pretreatment of ginseng ,but not affected in mongolian dogs.
3. The blood sugar level, serum transaminase (GOT and GPT) activities and alkaline phoshatase activity in rabbits and dogs induced by the administration of alcohol were affected by the pretreatment of ginseng. Because those were included -within normal ranges, the differences have no remarkable significance.
4. Liver alcohol dehydrogenase activity of rabbit was increased by the treatment of ginseng, especially it was markedly increased by the treatment of red .ginseng
5. The average lethal dose of alcohol to mice was increased by the pretreatment -of ginseng, especially it was markedly increased by the pretreatment of red .ginseng.
6. In the clinical experiments, the blood alcohol concentration induced by alcohol administration was not affected by the pretreatment of ginseng whereas the blood _sugar level was increased.
Blood alcohol concentration and blood sugar level were measured after three .hours alcohol administration.
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